- A second crossover with the original series has been confirmed to happen sometime in 2022.  The crossover will last two hours.
- A storyline continuing off the revelations of "Dust to Dust", and how the 126 crew will "not take no for an answer". 
- An "Owen Begins" episode showing the time Owen was going through 9/11.
- Rob Lowe as Owen Strand
- Gina Torres as Tommy Vega
- Ronen Rubinstein as TK Strand
- Sierra McClain as Grace Ryder
- Jim Parrack as Judd Ryder
- Natacha Karam as Marjan Marwani
- Brian Michael Smith as Paul Strickland
- Rafael Silva as Carlos Reyes
- Julian Works as Mateo Chavez
- Brianna Baker as Nancy Gillian
Behind the Scenes
- On May 25, 2021 it was announced Brianna Baker, who portrays paramedic Nancy Gillian, would be upgraded to the main cast for this season. 
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