The season premiered on September 20, 2021 with "Panic".
Production of Season 5 began on July 12, 2021 and is expected to conclude on March 16, 2022. 
As the fifth season of 9-1-1 opens, the first responders race into action when a series of ransomware attacks target computer systems, air traffic control towers and hospitals. Then, a massive city-wide blackout causes havoc in L.A. Meanwhile, Athena deals with a family emergency, Maddie’s postpartum depression worsens, Eddie suffers a health scare, and a new call center operator takes charge.
- The crisis to strike LA at the beginning of the season will be a blackout, revealed by its first teaser trailer on July 19, 2021.
- The blackout emergency will span the first three episodes of the season.
- Another crossover with its spinoff series has been confirmed to happen sometime in 2022.
- The exploration of Maddie's struggle with postpartum depression, and it leading to major complications.
- Albert Han's journey into becoming a firefighter.
- Athena will be dealing with her attacker, the serial rapist she caught and arrested at the end of Season 3.
- Angela Bassett as Athena Grant
- Peter Krause as Robert Nash
- Jennifer Love Hewitt as Maddie Buckley
- Oliver Stark as Evan Buckley
- Aisha Hinds as Henrietta Wilson
- Kenneth Choi as Howard Han
- Ryan Guzman as Edmundo Diaz
- Rockmond Dunbar as Michael Grant
- Corinne Massiah as May Grant
- Marcanthonee Jon Reis as Harry Grant
- Gavin McHugh as Christopher Diaz
|No.||Title||Directed by||Written by||Airdate||Viewers (million)|
|1||"Panic"||Bradley Buecker||Tim Minear & Juan Carlos Coto||September 20, 2021||5.08|
|A series of ransomware threats leads to an overabundance of emergencies for the 118, including a medevac helicopter crash at a hospital and an air-traffic control tower system failure. Meanwhile, Athena must revisit her traumatic attack when the case of the realtor serial rapist goes to trial, Eddie suffers a health scare and Maddie’s postpartum depression worsens.|
|2||"Desperate Times"||Bradley Buecker||Lyndsey Beaulieu & Andrew Meyers||September 27, 2021||5.45|
|The 118 springs into action when a city-wide blackout and a record heatwave causes mayhem in Los Angeles. Meanwhile, Chimney confides in Hen about Maddie's condition and Athena's worst nightmare comes true.|
|3||"Desperate Measures"||Ben Hernandez Bray||Kristen Reidel||October 4, 2021||5.25|
|As the citywide blackout continues to cause mayhem in Los Angeles, Athena races to save her family from a tragedy. Meanwhile, Eddie must make a difficult choice about his future and Maddie makes a life-changing decision.|
|4||"Home and Away"||Brenna Malloy||Bob Goodman||October 11, 2021||TBA|
|The members of the 118 arrive on the scene after a truck crashes into a high school homecoming parade. Meanwhile, Athena and Michael try to help Harry in the aftermath of his kidnapping, May is intimidated by returning call center legend and Bobby gives a devastated Chimney advice regarding Maddie.|
|5||"Peer Pressure"||Joaquin Sedillo||Nadia Abass-Madden||October 18, 2021||TBA|
|The members of the 118 face an awkward rescue call when they arrive on the scene of a man who has over-exerted himself exercising. The team also must save the life of a groundskeeper whose chainsaw cut into him and race to an explosion at a retirement community. Meanwhile, Athena has an extreme reaction to Harry's new behavior. Then, Hen and Eddie, as well as Buck and Ravi, have rocky starts to their new partnerships, and May receives an emergency call from a suicidal teen, while continuing her uneasy work relationship with Claudette.|
|6||"Ghost Stories"||TBA||TBA||November 1, 2021||TBA|
|The members of the 118 race to rescue a man who claims he was carjacked, shot and buried alive. Then, they arrive at a home where the owner thinks her roommate is a ghost, Hen receives a visit from the past and Athena and family are concerned that Harry is still haunted by visions of Jeffrey.|
- Gavin McHugh announced they had started filming for Season Five, via his Instagram, on July 22.
- The first official promotional video for the season was posted on July 20th, but it was later taken down due to licensing of “Paint It Black” by the Rolling Stones being used in the promo expiring. A different promotional video was posted later on August 10th.
- On July 28, filming for parts of Episode 1 and 2 of Season 5 took place on a stretch of Hollywood Boulevard and at Hollywood & Highland shopping center.